Schematic of the experimental setup. Ions are generated from solution in a nano-ESI source and transported into the gas phase of a high-mass modified Q-ToF mass spectrometer to a microchannel plate (MCP) detector. As they fly past, they intersect perpendicularly with X-ray/EUV photons in a radially confining hexapole between the collision cell and the ToF analyzer. An optical viewport and a Ce:YAG screen were used to aid the alignment of the setup with respect to the photon beam. Magenta labels show the optional ion mobility device used for conformational separation and the collision cell (CC) exit lens used to temporarily trap ions as described in the main text. The inset illustrates the photon delivery structure of both the quasicontinuous PETRA III synchrotron (equally distributed pulses with 16 ns or 192 ns bunch spacing when operated at 62.5 MHz and 5.2 MHz, respectively) and the unevenly pulsed FLASH2 free-electron laser used for the reported experiments. (Credit: Original publication in Phys. Chem. Chem. Phys)
